Glutathione: Defense Against Aging & Diseases

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The Ultimate Glutathione Supplement

The verdict is out – Keeping yourself healthy, preventing disease and aging well depends on keeping your glutathione levels high.

Glutathione is not a new fad, though very likely, you have not heard of it before. It was discovered more than a century ago and there are more than 100,000 scientific studies and citations concerning glutathione in PubMed, yet this little-known queen still languishes in the shadows of mainstream medicine.

What is glutathione? Reduced glutathione (GSH) is a linear tripeptide of L-glutamine, L-cysteine, and glycine. The secret of its power lies in the sulfhydryl (SH) group it contains. The SH group is a sticky, smelly molecule, which acts like fly paper, trapping all the bad things in the cell, including free radicals and toxins like mercury and other heavy metals.

As electrons are lost in neutralizing the free radicals or recycling other antioxidants, the molecule becomes oxidized, and two such molecules become linked (dimerized) by a disulfide bridge to form glutathione disulfide or oxidized glutathione (GSSG). This linkage is reversible upon re-reduction.

So how do we increase glutathione levels in our body? Before I go into detail on how you can do that, let me first clarify what you can’t do. You can’t take a supplement containing reduced glutathione; oral supplementation of glutathione just doesn’t work, which probably is one of the reasons why so little attention is given to its importance. When healthy subjects were given a single dose of up to 3,000 mg of glutathione, researchers found there was no increase in blood glutathione levels. (Witschi A, Reddy S, Stofer B, Lauterburg BH. The systemic availability of oral glutathione. Eur J Clin Pharmacol 1992;43(6):667-9.)

So, please don’t rush out to your nearest health food store or pharmacy to grab your bottle of L-Glutathione before you have finished reading this article; all you’ll get is a very healthy toilet!

So then, what can you do to raise glutathione levels in your body significantly? The best way is to provide your body with the right precursors so the cells can produce glutathione endogenously on their own. Now, let’s go back to the three components that make up glutathione. Of the three, cysteine is the most important. It is the one that contains the SH group which neutralises free radicals or interact with another molecule with an SH group. It is the rate limiting factor, and is considered a conditionally essential amino acid, meaning if the body cannot make enough; it must be ingested.

But hold it, you can’t rush out to buy a cysteine supplement either – that won’t get you very far as ingesting free cysteine will only get you a lot of cystine – two cysteine molecules linking with each other through the SG groups.

Supplementation with Glutathione Precursor
How would you select an effective glutathione supplement, or more accurately, a glutathione optimizer?

The ultimate glutathione optimizer would have the following elements:

  • Protected form of cysteine to ensure its SH group stays intact until it is used to produce more glutathione in the cells.
  • Components to promote continuous recycling of oxidized glutathione GSSG to two molecules of reduced glutathione GSH.
  • Components to stimulate/maximize enzymes involved in controlling intracellular glutathione functionality and levels.
  • Cofactors to facilitate both glutathione and ATP production.

Based on years of extensive research led by the late Dr Keller and independently by renowned medicinal chemist and scientist Dr Herbert Nagasawa, here are some of the proposed ingredients that will help optimize glutathione levels in our body:

  1. Alpha Lipoic Acid – a powerful endogenous antioxidant known to combat various forms of oxidative stress and to recycle other antioxidants. Together with glutathione, they protect the fat and water portions of the cells from different types of free radicals.
  2. Broccoli Seed Extract (sulforaphane glucosinolate) – acts as a catalyst to boost antioxidant activity for as much as three days. Protects against DNA damaging electrophiles and helps cells neutralize toxins and carcinogens so they are eliminated from cells. It also helps to raise and replenish glutathione levels and induces the antioxidant enzymes used in the Phase II detoxification pathway.
  3. Turmeric Root Extract (Curcumin) – a potent antioxidant that fights free radicals and is known to reduce inflammation. Curcumin also induces Phase II enzymes that support the glutathione detoxification pathway.
  4. Resveratrol – is an antioxidant found in high concentrations in grape skin, also found in wines, with higher concentrations in red wine versus white wine. Resveratrol is thought to account in a large part for the so called “French Paradox”. The French Paradox – the findings that the rate of coronary heart disease in France was observed to be lower than in other countries with a similar risk factor – has been attributed to the consumption of red wine. Resveratrol is an antioxidant known to have cardio-protective properties.
  5. Grape Seed Extract – Grape Seed proanthocyanidines have antioxidant activity, as well as anti-inflammatory properties.
  6. Quercetin – a supporting flavonoid antioxidant that scavenges free radicals that can damage cells.
  7. Milk Thistle (silymarin)– a powerful antioxidant used to support a healthy liver by removing harmful toxins and heavy metals that are stored in the liver.
  8. Vitamin C – an exogenous antioxidant that is considered a network antioxidant and known to support the immune system.
  9. Selenomethionine (Selenium) – the essential catalytic component of the enzyme glutathione peroxidase (GPx) and is absolutely required for its function. The glutathione peroxidase enzyme is responsible for the detoxification of lipid peroxides, and glutathione is absolutely required to regenerate this enzyme.
  10. Cordyceps – has been used as a Chinese medicine for centuries and has been valued for its activity in restoring energy, increasing stamina, promoting longevity and improving quality of life.
  11. Black Pepper (BioPerine)– assists in the absorption of Selenomethionine, Vitamin C and Curcumin (turmeric root).
  12. Aloe Extract – has the most bio-active content of acemannan, the active ingredient in aloe. Aloe is known to support the immune system and has antioxidant functions.
Cellgevity: The Ultimate Glutathione Optimizer

Cellgevity

The result of more than 25 years’ research is a breakthrough product called Cellgevity. Cellgevity is powered by RiboCeine, a patented nutrient compound that has been shown to effectively deliver the key precursor nutrient cysteine directly into the cells. Unlike any other nutritional compound, RiboCeine has been the subject of todate 24 published, peer reviewed scientific studies funded by the National Institutes of Health and other scientific institutions. RiboCeine has significantly outperformed all other means of glutathione enhancement against which it has been tested, with an amazing result of raising liver glutathione levels by an unprecedented 300%!

In addition to RiboCeine as the delivery vehicle for cysteine, it also contains a synergistic blend of the 12 scientifically proven ingredients listed above that support glutathione’s vital role in removing harmful toxins, eliminating cellular inflammation and neutralizing free radical damage in the body.

To order Cellgevity or read some of the testimonials, go to Glutathione4Health.

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